Veterans’ high rates of HCV much worse than previously thought

download (2)Results from a large VA study provides evidence of severe HCV outbreaks in U. S. boomer veterans who visited the VA at least once in 2011.  They looked at lab results going back about 12 years. This table show the prevalence of HCV infection by birth year–with 1954 having the worst odds.

hcv birth va

Prevalence of Hepatitis C Virus Infection by Birth Year
VA Data

Black men in the boomer cohort were the hardest hit at 18.2%.  

hcv black

I’ll post the whole study when I get it from the VA.  (It’s currently on JAMA)

The study provides data for anti-HCV and HCV infections (page 2) for those in VA care in 2011 who were screened–about 53.4% of 2.8 million veterans.  This doesn’t include those in private care but the nuanced language is pessimistic.  If you think about veterans as a population/cultural group that then scattered (returned home) I think the word hyperendemic seems more suitable than the tamer “outbreak.”

We know that there are many methods of transmission for this opportunistic virus but there was a definite amplification during this period.  And no, black men did not join the Army, Navy, Air Force and Marines, go through boot camp and training hoping to get sent to Vietnam and shoot up cheap drugs while dodging bullets and missiles.  Those insulting stereotypes are what many esteemed researchers would like us to believe.

According to epidemiologists, HCV entered the United States during the slave trade.  The slave ship routes also explain the higher rates of Hispanic infections.  HCV was transmitted inefficiently from person-to-person for a long period. But then new types of health care services were invented amplifying the spread of HCV–and war activities provided perfect opportunities for transmissions:   Dirty blood was used in transfusions, the source of blood eventually came from a “closed loop” source, unsafe mass injections via jet injectors, multi-dose and dirty syringes were used, unsafe sex was engaged in, combat blood exposures were common. The tattoos, village barbers, sharing personal care items, surgeries, gamma globulin, dental procedures, lack of VA infection control, and so forth all combined to create this vile unhealthy and devastating crisis.   Good intentions led to misery and the medical cover-ups we still are dealing with.  Why do more males have HCV?  Well, males do risky things like join the military.

These ideas need to be repeated as the concepts become clearer and the facts are gradually illuminated by science because the information is being released piecemeal by public health professionals and other interested parties.

Ed. note. I have talked with numerous Veterans who eventually obtained their VA medical records and were shocked to discover VA had tested them in the early 2000s and never told them they were positive for HCV. Imagine a medical organization who couldn’t be bothered to notify a Veteran that he was dying from an insidious disease that could be cured (if Interferon could be called such.)

Posted in Guest authors, HCV Health, HCV Risks (documented), Jetgun Claims evidence, Obtaining a C-file, VA Health Care, vA news | Tagged , , , , , , , , , , , , , , , , | 4 Comments

VA INFO ON INTERFERON SIDE EFFECTS

download (1)Amazing. VA is actually telling us what the rat piss they shot into us does. All of you filing for residuals of Interferon/ HCV can use this a prima facie evidence, seconded by the ones who did it to you as a tacit admission to what it will cause. This is boomerang medicine. VA is providing you with the tools to file claims with VA’s own nexus letter preprinted with their letterhead. What could be simpler. “You poisoned me. Here’s the link. Pay me.”

Posted in Interferon claims, Tips and Tricks, VA Health Care, VA Medical Mysteries Explained | Tagged , , , , , , , , , , , , , , , , , , , | 6 Comments

NEW LEGISLATION TO EVICT VA DEADWOOD

njGreat article from Pop Smoke on Republicans actually reaching across the aisle in a bipartisan effort to fix the VA. I like it. Sen. Cruz introduced it in the Senate as well so we shall see who the poker players are and if they’re interested in our welfare.

Posted in VA BACKLOG, VA Bonuses, vA news | Tagged , , , , , , , , , , , | Leave a comment

CAVC–MEKUS V. SHINSEKI–IDLE HANDS ARE THE DEVIL’S WORKSHOP

downloadGiven that there’s a backlog that would reach from Seattle to Honolulu if all the Vets lined up, you would wonder how on earth anyone would have to time to pick and dig and come up with this idiotic CUE. We often hear about how VA, if they feel jilted or slighted by you, will come after you like a scorned woman. It is rarely true but when it happens, we often find out it was the cold case files team. Rarely do they run amok off the reservation like they did to Keith Roberts.

Considering it takes 16 months to to get your dependents added to your claim, we here at Asknod ask the burning question. “Who had time to excavate Christopher A. Mekus’ file and start parsing Diagnostic Codes to knock down what appeared to be a firmly established Permanent and Total rating?” DRO reviews out of Oakland are running 585 days. That’s after 16 months waiting for an initial denial to generate a Notice of Disagreement. Quite simply put, what outfit in the VARO had the time to excavate paper files and peruse them minutely for error? This is all pre-VBMS. They had to go to the basement and dig this one up. And for the record, there is no Cold Case Files to my knowledge. which means they have an alarm clock for old claims…

So what happened? Here’s the case and I’ll tell you  in case your’re too lazy to read it.

Mekus v. Shinseki

imagesChris was a zoomie from 1985 to 88. He filed a claim for some weird stuff growing on his left hip that turned into a nasty surgery. It didn’t get better. He got the standard temporary prestabilization rating of 100% that we all get after a debilitating surgery in January of 1989. At his exam, he was on those skanky Canadian crutches we associate with Forest Gump or a polio victim in the 50s. At any rate, he had some mega issues with mobility which normally gets you a rating for it. By February of 1989  he was hors d’combat and not walking at all.

Following Chris’ April 1989 routine exam, the VA continued his 100% under a weird (read wrong) Diagnostic Code of 5012 instead of 5020. This was VA’s conception of CUE and what he would be fighting years to overcome in the distant future. The 100% was legitimate. As usual, a year later they gave him the progress exam and it revealed even more problems with pain, mobility and being able to stand for any period of time. Driving was getting difficult due to leg immobility. The Raters gave him a continued 100% and scheduled him for another show and tell in two years. This is VAspeak for a future Permanent and Total rating. When you come back two years later and are either the same or worse, they issue the Full Meal Deal. $10,000.00 in free VGLI whole life policy, college for the whole fandamily, and shopping at the commissary /PX nearest you. Oh, and “free” medical at the VAMC.

Sure enough, March 1992 dawned and Chis was still in the same boat or slightly worse. In June, VA issued a confirmed rating decision of Permanent and Total (P&T) and told him he didn’t need to ever come back for no more C&Ps. Now for the misfeasance.

At the end of ten years of Permanent and Total, a milestone occurs. To wit: your spouse, assuming you’ve been married over a year, is eligible to be awarded DIC or Dependents Indemnity Compensation of about $1500 a month for life. This happens when you become room temperature. Since you’re dead, there is no compensation check for $3K coming into the autodeposit. Widows of P&T Vets are the only ones who get this. It’s tax free which means she also gets the SSI.

Suddenly, in June 2002, VA was  industriously sniffing around Chris’ P&T claim from June 1992. Sure enough, the dang rating was CUE and fortunately for everyone involved, the VA had discovered it and had to set things right legally. Everyone but Chris was going to be happy with this discovery. They whacked his 100% P&T back to 60% but pasted on TDIU. On paper, this does not change the autodeposit of $3K every month.  The only problem was that Mrs. Mekus just got screwed.

In order to appear munificent, VA had reduced Chris’ ten year old rating, mind you, with no medical examination, and changed it to what they considered the proper 60%. The munificence was the concurance that he could not work and the Total Disability for Individual Employment (TDIU) was thrown in as the appeaser. Where the problem arose was that Mrs. Mekus’ DIC clock was reset From June 4, 1992 to June 4, 2002. Chris would now have to live another ten years in order for the Missus to be back in the DIC saddle.

Mr. Mekus dutifully appealed and they buried it in an endless four-year remand which resulted in a new denial from the Veterans Law Judge in 2008. Surprise! Wrong Diagnostic Code! Nobody bothered to drop by Chris’ place for a beer summit and a game of horseshoes or they might have noticed Chris was and had been legitimately disabled since all this began.  And he didn’t have a horseshoe pit. Nobody. Hell, not even the Keystone Kops from the OIG peeked in the window. All this over what ultimately resulted in resetting a DIC clock! Lord. How many man hours do you think this ate up just to arrive at the CUE-let alone another twelve years of litigation?

Mr. and Mrs. Mekus’ claim finally was heard at the Court in April 2010 and remanded for a wealth of stupidity on the part of the BVA. The CAVC judge clearly threw them the lifeline to get out of this  but the Veterans Law Judge wasn’t biting. He continued the denial based on a wealth of poor law. Again, no one disagreed with how disabled Chris was. They just disagreed on the Diagnostic Code rating chosen. For shits and grins, let’s go with the original, proper one of DC 5020. It would change nothing. It’s a number. VA said no, he had to be initially rated under metastases of cancer/recent surgery and  then should have been assigned a new DC after it stabilized. First of all, 100% is 100% regardless of what DC you choose. Then, having announced CUE,  they changed it to DC 5255- again the wrong one, in 2002. Here on appeal, they are arguing about analogous ratings and the appropriateness of that. The argument is specious at best and the judge hangs them on it. If DC 5012 was inappropriate and rose to the level of CUE in 1989, then why would rating him under the incorrect DC 5255 in 2002, rather than the correct DC 5020 NOT be CUE yet again? The VA Secretary tried to moonwalk backwards out of that one but never got traction on the tenny runners. Here’s the Mobius Loop Logic.

 The Secretary argues that the Board correctly determined that the June 1989 RO decision was the product of CUE because it should not have rated the appellant’s PVS by analogy (DC 5012).

Assuming, as the Board did, that rating by analogy under DC 5012 was appropriate, the Secretary also argues that it was error to continue the appellant’s rating more than one year after the October 1987 surgery because there was no evidence that the appellant had undergone any additional surgical intervention, chemotherapy, or other therapeutic procedure, and no evidence of local recurrence or metastases.

True… but if you compound the CUE with a new one, the Court gets the impression you really don’t know what you’re doing anyway.

In his reply brief, the appellant reiterates his assertions that PVS and synovitis are not the same conditions, and asserts that the Board’s decision was arbitrary and capricious because the Board contradicted itself when it found that the appellant’s condition is “listed” under DC 5020, but proceeded to rate him under DC 5255 after it affirmed discontinuance of the rating under DC 5012.

When we assay to prove CUE in a VA decision, we encounter the normal obstacles most Vets are essentially apprised of. Again, think of it as a recipe of ingredients with some substitution allowed. First and foremost, the meat.

1) the correct facts contained in the record were not before the adjudicator,   OR

2) the statutory or regulatory provisions in effect at the time were misapplied.

AND

Phase two, if either one of the prior conditions is met, engages the second  measurement:

3) the alleged error must be “undebatable,” not merely “a disagreement as to how the facts were weighed or evaluated.”

The third prong is what is unarguably the hardest for Vets to prove and the one that most fail to make.

4) the error must have “manifestly changed the outcome” of the decision being attacked on the basis of CUE at the time that decision was rendered.

What many overlook is in the preface and is almost another set of rules unto itself.

1)”Previous determinations which are final and binding, including decisions of . . . degree of disability . . . will be accepted as correct in the absence of [CUE].

2) When the Secretary initiates revision of a prior final decision, the burden is on the Government to establish that the prior decision was the product of CUE.

And last but not least…

It is the kind of error, of fact or of law, that when called to the attention of later reviewers compels the conclusion, to which reasonable minds could not differ, that the result would have been manifestly different but for the error.”

images (1)

Judge Mary Schoelen
(who else?)

VA was so hell bent to hand Mr. Mekus a CUE that they failed to make their case. I find it interesting here that this one finding below would be enough to overthrow the CUE motion by VA. The Judge keeps on going like the Energizer Bunny and identifies each and every error in minute detail. Reversals are very messy and leave a lot of blood on the floor. This one was no different.

In June 2002, the RO determined that the rating by analogy to DC 5012 amounted to clear error because there was “no malignancy,” and the Board affirmed that finding in the decision on appeal. The Board stated “[a]lthough 38 C.F.R. § 4.20 permits an evaluation of an unlisted condition under the [DC] for a closely related disease or injury, synovitis is a listed condition.” The Board, however, did not cite any medical evidence in the record to support its determination that synovitis and PVS are the same medical condition, and the Secretary makes the same omission when he argues for affirmance of the Board’s determination.   Without independent medical evidence to support its decision, the Board impermissibly made a medical determination that cannot provide the bases for finding the 1989 final RO decision, which is presumed correct, clearly and undebatably erroneous. See Colvin v. Derwinski, 1 Vet.App. 171, 175 (1991)

Contrary to the Board’s conclusion, its reasons for finding DC 5012 an inappropriate analogous rating code do not establish clear error in the RO’s decision. In fact, the reasons provided by the Board support the RO’s selection of DC 5012, or at the very least show that reasonable minds can differ on whether DC 5012 is a closely analogous code for the appellant’s PVS.

Given the evidence of record in 1989 and the Board’s recognition that the appellant’s PVS can recur and have malignant symptoms, the Court finds the Board’s determination that there was CUE in the selection of DC 5012 “arbitrary, capricious, an abuse of discretion, or otherwise not in accordance of law.”

The Board’s finding that there was “absolutely no evidence . . . functionally or anatomically analogous to ‘local recurrence or metastases’ of a malignant tumor” but only evidence of residuals of the surgery amounts to nothing more than a disagreement with how the RO weighed the evidence in 1990 and 1992, which cannot constitute CUE.

Mr. Mekus’ counsel has aptly made his case but he should never have had to. Now the Government is on the hook for all those EAJA fees. CUE is interesting. When it is stirred into a reversal, it makes for a good yarn. When shaken by Judge Mary Schoelen, it’s bound to be a classic.

Posted in CAVC Knowledge, CAVC ruling, CUE | Tagged , , , , , , , , , , , , , , | Leave a comment

VAMC–PASS THE CRACK PIPE, PLEASE

Proudly killing Vets  for over two hundred years

Proudly killing Vets for
over two hundred years

Yeppers. Got it first hand from my VAMC Personal Care Physician (PCP), Rose M. Sessoms, M.D. that my liver “appears to be functioning well.” We have to wonder if Rose got her doctor’s license in some third world country that requires 40 hours of course work or if she has been smoking some of Washington’s now legal whacky tabacky. This doesn’t strike me as a form letter. And you wonder why I won’t ever let them cut on me again?

Click on these images to magnify them so you don’t destroy your eyesight. I paid good money to have this feature provided here.

2014-02-13 1142182014-02-13 114304

Posted in Medical News, VA Health Care, VA Medical Mysteries Explained | Tagged , , , , , , , , , , , , , , , , , | 9 Comments

$180,000.00 LOTTO FOR LIFE

imagesToday was THE DAY. The ARNP popped blue smoke and arms out to line up a landing. Solvaldi time is one month to guns hot. I’ve been waiting for this for seven years so it’s a milestone in my life even bigger than kicking ass with VA. Well, actually I’ve been waiting for this since I got the bug in 1970. I just didn’t know I was dying from it.

ARPN Tobi Ann showed me the magic chart for dummies that illustrates the word Genotype 3 in  bold 48-point followed by the words Sovaldi + Ribavirin X 24 weeks just in case I was out of the loop on this.

I will be SVR within four weeks guaranteed according to Miz Tobi. If I never attain SVR, I will still inhibit the bug so greatly that I’ll probably die of old age. 83% chance of success is the prediction.

download (1)The last admonition was that I was going to consider Miz Tobi as Nurse You-know-who before this was all over. She stated in no uncertain terms that blood tests, when ordered, shall be complied with RFN. Fair trade. My life for six months of inconvenience?

So, let me see if I get this right. $180,000.00 worth of medication, all my blood labs, a new shot at living out my natural life, quite possibly the remission of the majority of the autoimmune issues I currently suffer including the Autoimmune Hepatitis, gradual restoration of part of my liver, improved liver function, pruritis remission-basically my life back- all for six prescriptions times $5.00 per copay for a total of $30.00? What’s the catch?

I must be in heaven, man. I haven’t felt this way since 1969. It was my graduation present. Two tickets to three days of a Music and Arts Festival in upstate New York. 450 yds out @ 5 o’clock.  The idea of living just gives me a shit-eaten grin tonight. Thank you Big Pharma. I finally passed the audition.

8/16/ 1969 Wavy Gravy states "We must be in Heaven, man!"

8/16/ 1969 Wavy Gravy states
“We must be in Heaven, man!”

CLEAR PROP!  

Posted in Medical News, Sofosbuvir | Tagged , , , , , , , , , , , , , , , , , , | 8 Comments

THE FACE PLACE

1922326_10152072086180914_1456280481_nThis is where America gets its humor on short notice. Johnny Carson would have been proud. He could have fired his whole stable of jokesters and harvested the jokes du jour off of FB. Perhaps we could call Governor Christie’s dilemma a “plus size” misunderstanding. Peut- être un mésentente le plus grand, n’est-ce pas?

Posted in FACE HUMOR | Tagged , , , , , , , , , | Leave a comment

WANTED–WILLIAM DEREK CHURCH

doc11Here’s another one of those “Be all you can be” guys. Five-week wonder Sargent. There must be a barcolounger near the fireplace in Hell for these guys. Here’s a .pdf closeup so you don’t have to use a microscope to look at the idiot. My thoughts– What? No Congressional Medal of Honor? Dude, you were ripped off. Church_Poster_PDF. Great little website, too.

Posted in Stolen Valor | Tagged , , , , , , , , | 2 Comments

VA CLAIMS–SUBMITTING PHOTO EVIDENCE

Many Veterans have contacted me about submitting photo evidence and what constitutes an acceptable form by VA.  Our resident dermatologist, Jules, and proud recent member of the 100% P&T club here has clued me in to the requirements.  My attorney extraordinaire, Bob “I make it rain” Walsh even proffered me a form. I hereby share it with all of you. Now follow me on this. 

Photo Form

First, it’s a “live round” Microsoft word doc. It’s ready to modify in it’s current state. I left a static date in the correct format in place to show how it looks ( 01/10/2014). You can change it. Hit “enable editing” in the top yellow bar and you’re live.

Now, this is easy. Here’s a screenshot for all of you. Click on it once to magnify. Place your cursor at the top left like the one in the picture below and then go to the top with the mouse monkey. I call the thing that follows your mouse…nevermind.

screenshotUp in the top left on M/S Word is the action bar for insert next to home. Click on insert and choose “picture” down and to the right below it. This opens another menu of your computer to choose either a picture from your albums or something you have saved and are ready to insert into the Microsoft Photo file.

Next, while poised on the item/picture of your choice, illuminate it by left clicking on it once. Next, return to the bottom of the window and click save.  Fill in the block below and add in the appropriate info as necessary. I’ll screenshoot another finished copy example for you.

doc 3Next, if you are satisfied with the finished product, you want to protect it against tampering by anyone at the VA. Think of it as helping them to keep themselves honest. Move your mouse monkey up to the FILE tab in the upper left where the insert and home tabs are and click it. Choose SAVE AS.

When the next window opens to save it on your computer, I put them on the desktop because I never can find them if I blindly hit okay. It’s like socks to the washing machine. First, name it where it says File name. I like to use  Ask Joe Nod, 004 Right Arm .  Just below it, it asks what file format you would like to save it in. It says Save as type. Click on that bar and a menu drops down. Choose PDF. This pours cement around it and it stays put more or less in this form. It’s a smaller file size than a ,jpg, .tif or .png file and will upload to eBenefits more easily if you should choose to take that risky path. Last, but not least, go to the bottom right and click SAVE.

doc 4Once it’s saved you can open a new file, name it and put all the .PDFs in it. When you need it you can print them up to send in to rebut the denial. But we know you guys and gals are red hot and win them all at the VARO nearest you. This is just one more way to hit one out of the Veterans Service Center when you first come to bat.

Now we’re going to go the extra step that will professionalize the production. Here’s the download to a free ruler you can print. It is accurate. Even though we live in America, dermatologists live in centimeterland- east of the Land of Nod. A Stanley 30-foot metal construction tape is right out. Cut off about 5 cm. of your free new cm. ruler and write your full name, rank and airspeed on it including the date.

Ask Joe Nod    XXX-XX-XXXX  2/11/2014

This is a must have. Every picture must have one and adjacent to what it is you are trying so desperately to draw the rater’s absent-minded attention to. You can see the top edge of the one in the picture above. I cropped it out.

This will help you win your claims. VA will try anything to toss the evidence out or claim they cannot decipher it because it does not conform. What they won’t tell you precisely is what it was that made the picture inadmissible. This format is VA-bulletproof. Of note, this conforms all the way up when they demand stricter protocols for evidence in the Record Before the Agency (RBA) or above (Record of Proceedings or ROP).

Posted in Nexus Information, Tips and Tricks | Tagged , , , , , , , , , , , , , | 5 Comments

GILEAD TO PAIR LEDISPASVIR WITH SOVALDI

downloadThis morning I read with great satisfaction that Gilead Sciences is proceeding with yet even more studies on Ledipasvir combined with Sovaldi (Sofosbuvir), with and without Ribavirin. What is noticeably absent is the mention of the dreaded bug juice- Interferon.

For over a decade we have been subjected to more and more new, improved products that swore to be able to kill the dragon. Each one ratcheted up a few percentage points in success but none even came close to the magic 80% and beyond. In fact, if you go back to the early Interferon days, we were shooting up what would be considered a week’s dose in one shot. People who did this are either no longer with us or are so compromised as to be mushrooms in the basement. Actually, if you were to even contemplate that size a dose today, doctors would tell you it was a death wish. Where the hell were they when our good friend Mark of recent VA win fame was told it was okay to shoot up two doses a week instead of one (of the huge doses) as it would probably hasten his SVR. This brain fart came from-who else- VA doctors.

download (1)

Why, I almost diiiied!

The advent of Ribavirin was heralded as the panacea to knock this bug on its ass. If you consider an increase in SVR (Sustained Virologic Response aka a cure) from 33% to 37% a watershed event, then you were a born optimist. When I took my first shot April 12th, 2007, I was told I had a 66% chance of killing it (genotype 3A) within 26 weeks. Unfortunately, they neglected to read their own baseline testing and spot the autoimmune issues staring them in the face. Much like Roseanna Rosannadanna, I almost died.

The next big invention (that is actually still being promoted) was the triple drug cocktail involving Telepravir/Boceprivir combined with our other two old friends Interferon and Ribavirin. The percentage of SVRs continues to go up but they in no way shape or form got to the magic land above 80-85%.  How about 65% if you could stand the side effects long enough to attain remission? Recently, Vertex pharmaceuticals, the makers of  Teleprevir, sold out their product for $152 million- in effect conceding the future of protease inhibitors is going down the tubes. Smart choice. I suspect it won’t be long before Merck-Victrelis (Schering-Plough etc.)(Boceprevir) and the others follow suit assuming they can find someone interested in buying it.

I think the biggest 800 lb. gorilla infestation that resided on the living room sofa all these decades was  the continued insistence that Interferon caused no more than”flu-like symptoms”. More recently, the Vertex/Victrelis cheerleaders were saying it causes “diarrhea”.  Pardonnez moi. I beg to differ. Everyone, and I do mean everyone I’ve talked to, that has used Interferon has a far different take on it. Since when did downstream issues after the flu entail going blind, thyroid cancer, endless depression, anemia,  malaise and making your teeth rot out of your head? If you were watching TV and the announcer started running off a litany of things (as they currently do) that might be considered adverse effects, like having a stiffy for over 4 hours because you really wanted to be all you could be in bed, you’d nod sagely and say ” Ne problemo.-not me”. But if that same announcer began with “If symptoms continue or you notice your teeth falling out, discontinue use and call your doctor. Has caused thyroid cancer in most lab rats. May cause blindness and major clinical depression to include thoughts of harming oneself. As with all drugs, results may vary.”

I have read extensively about Interferon since its discovery in 1959. The wonder drug, touted as being nothing more than a ” medical leg up” and “something your body manufactures naturally”, was initially produced and proclaimed a cure for cancer. Funny how that story changed in a hurry. I notice cancer is not on the verge of disappering any time soon. Again, in the late eighties it was trotted out as the new panacea for AIDS. That revelation quietly died (along with a lot of AIDS sufferers) and we didn’t see it appear again until the mid-90s when-guess who- arrived. Each succeeding “medical breakthrough” on this drug was accompanied by the “Let’s just give it a chance to work. We know it works. Some just need to do it several times to kill the bugs.” This idiotic mindset that the drug was (and is) safe has festered now for over forty years. The trail of destruction in its wake is amply documented but they still drag it out as some kind of wunderdrug with acute, non-life threatening consequences.

Gilead has been combining it in a new triple drug therapy with Sovaldi and Ribivirin as the go-to combo to kill  recalcitrant Genotype 1A and 1B.  When do you suppose they’ll get around to doing a retrospective study of the folks who were horribly maimed by the “flu-like symptoms” but never cured? Fortunately for us, the days of Interferon vis-a-vis HCV are coming to a close but not soon enough to avoid irreparable damage to yet even more souls. Sure, the new cocktail is 100% effective in 8-12 weeks but they’re still not talking about that 800 lb. Interferon gorilla. What is it about Interferon? Who owns this crap that allows them to keep producing it? It’s more insidious than Agent Orange.

Within a decade HCV will become as rare as Smallpox or Polio. The cure will not entail going blind or require a few blood transfusions to “bulk up’ on your platelet count. You won’t come down with horrible autoimmune disorders secondary to the treatment either. I personally have waited for a shot (pun intended) at this Interferon-free treatment for seven years praying it would show up before I hit stage 4 or hepatocellular carcinoma- the dreaded HCC called liver cancer. With Porphyria Cutanea Tarda, the odds jump 33% higher that I’ll get it (HCC). Sovaldi is merely the cusp of the revolution. When combined with Ledepasvir, it is expected that the SVR will climb into the high 90 percentile for all the genotypes. Eventually, genotype will have no bearing in the success rate. Gilead and the other companies will keep it on the shelf for the occasional outbreak in a third world country and we’ll all breathe a sigh of relief.

Gilead had an opportunity, and indeed did trials, with a combination of Sovaldi and Daclatasvir. The results were off the chart (almost 100% again and again) but Gilead couldn’t reach a modus vivendi with Bristol Myers over combining the two and splitting the profits. Without casting stones, I suspect Gilead, like any big company, wants it’s own sole-source drug and the concomitant profits associated with it. They’re apparently right. When you have the only craps game in town and the only pair of dice, you pretty much control the horizontal and vertical. Johnson and Johnson’s Olysio isn’t going to be a serious competitor. It’s a day late and a dollar short. Besides, it’s also a retread of the Telepravir/Boceppravir protease inhibitor line of products and is yesterday’s news -like Interferon.

Interferon for dummies

Interferon for dummies

The new paradigm is the NS5A inhibitor which is what Sovaldi is. Daclatasvir and Ledipasvir are, too. These are just the tip of the new drug iceberg.  Interferon was like the old Franchi-SPAS 12 gauge street sweeper. The collateral damage was never cataloged because they were too busy trying to prove it  was the miracle cure for Hep. If a majority suffered and fell by the wayside, well, tough shit. It worked for over 34% so get over it.  NS5A drugs do not run around and “shotgun” the HCV virus like Interferon did with its horribly predictable side effects. They work much like that goo you put between the shoulder blades of you dog or cat for fleas. Frontline® and its similar flea juice competitors interrupt the cycle of  flea-breeding. NS5As operate identically and work much like RU-485- the “day after” pill to prevent conception. Anyone with an ounce of sense can see taking a contraceptive is far more logical than opting for a risky 1950s-style, late-term abortion in a back room somewhere with a 34% chance of terminating the pregnancy.

download (2)Having talked with over a hundred of you lucky souls who were cured on the Gilead trials, the worst side effect I’ve heard of is itching and gastrointestinal issues like flatulence. I say that beats the pants off thyroid cancer and  incurable mental depression. Personally, I’ll take farts over blindness any day. Besides, for me it will be the longer 24-week course. For the majority of you, it will only be the eight, twelve or sixteen-week course. I’m stocking up on Febreeze and a back scratcher, dude.

The saddest part of this is that medical researchers were willing to sacrifice us on the altar and tell us we could hack the course and suffer no lasting side effects from the bug juice. In some respects, it mimics Thalidomide in the sixties. Little or no testing resulted in a generation of children disfigured for life. At least they were not killed outright in the pursuit of a cure for morning sickness. Small consolation in retrospect. I’m sure they’ll say the same of Interferon fifty years from now.

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